2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

Base Information

Chemical Name:2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone
CAS No.:80263-52-1
Molecular Formula:C₁₅H₁₆O₃Se
Molecular Weight:323.25
Hs Code.:

Synonyms:2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

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Chemical Property of 2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

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Technology Process of 2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

There total 4 articles about 2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34837-55-3
Phenylselenyl bromide

: 80263-51-0
2-(2-oxo-5-cycloheptenyl)acetic acid

: 80263-52-1
2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

Guidance literature:: With bromine; triethylamine; In dichloromethane; at -78 - -20 ℃; for 60h; Yield given;
DOI:10.1021/jo00343a018

Reference yield:

: 1666-13-3
diphenyl diselenide

: 80263-52-1
2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂ / CH₂Cl₂

2: 1.) Br₂, 2.) Et₃N / CH₂Cl₂ / 60 h / -78 - -20 °C

With bromine; triethylamine; In dichloromethane;
DOI:10.1021/jo00343a018

Reference yield:

: 19686-79-4
cyclohept-4-en-1-one

: 80263-52-1
2-<6β-hydroxy-2-oxo-5α-(phenylseleno)cyclohept-1-β-yl>-acetic acid lactone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, - 78 deg C, 1.5 h, 2.) -78 deg C, 1.5 h

2: KOH / ethanol / 1 h / 25 °C

3: 1.) Br₂, 2.) Et₃N / CH₂Cl₂ / 60 h / -78 - -20 °C

With potassium hydroxide; bromine; triethylamine; lithium diisopropyl amide; In ethanol; dichloromethane;
DOI:10.1021/jo00343a018