(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

Base Information

Chemical Name:(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one
CAS No.:1432054-04-0
Molecular Formula:C₃₄H₂₉F₉N₂O₄
Molecular Weight:700.601
Hs Code.:

(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

Synonyms:(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

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Chemical Property of (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

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Technology Process of (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

There total 15 articles about (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₃₇F₉N₂O₆

: 1432054-04-0
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1432054-04-0
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: column—OJ 250 mm×50 mm, 10 um / isopropyl alcohol / 38 °C / Resolution of racemate

3.1: Helmchen dibenzo[a,e]cyclooctatetraene (dbcot) iridium phosphoramidite catalyst complex / dichloromethane / 48 h / 33 °C

4.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride / toluene / 2 h / 60 °C / Inert atmosphere

5.1: Wilkinson's catalyst; hydrogen / ethanol / 2068.65 Torr

6.1: potassium acetate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / N,N-dimethyl acetamide / 20 h / 80 °C / Glovebox

7.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium phosphate / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With potassium phosphate; Wilkinson's catalyst; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); hydrogen; sec.-butyllithium; potassium acetate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; cyclohexane; water; isopropyl alcohol; toluene;

Reference yield:

: 175883-60-0
3-chloro-4-methoxyphenylboronic acid

: 1432054-04-0
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(5'-((2S,3S,4R)-2,4-dimethyl-5-oxopyrrolidin-3-yl)-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)one

Guidance literature:: Multi-step reaction with 4 steps

1.1: [Rh(OH)(cod)]2; potassium hydrogenfluoride / 1,4-dioxane; water / 60 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2.5 h / -78 - 20 °C

3.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium phosphate / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With potassium phosphate; potassium hydrogenfluoride; [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;