(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Base Information

Chemical Name:(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one
CAS No.:1432054-91-5
Molecular Formula:C₂₇H₂₅BF₉NO₄
Molecular Weight:609.296
Hs Code.:

(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Synonyms:(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Chemical Property of (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Technology Process of (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

There total 18 articles about (1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432054-90-4
(1R,5S,7aS)-1-[3,5-bis(trifluoromethyl)phenyl]-5-[2-bromo-5-(trifluoromethyl)phenyl]tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one

: 73183-34-3
bis(pinacol)diborane

: 1432054-91-5
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: With 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; potassium acetate; In N,N-dimethyl acetamide; at 80 ℃; for 20h; Glovebox;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1432054-91-5
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 0 - 20 °C

2: Helmchen dibenzo[a,e]cyclooctatetraene (dbcot) iridium phosphoramidite catalyst complex / dichloromethane / 48 h / 33 °C

3: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride / toluene / 2 h / 60 °C / Inert atmosphere

4: Wilkinson's catalyst; hydrogen / ethanol / 2068.65 Torr

5: potassium acetate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / N,N-dimethyl acetamide / 20 h / 80 °C / Glovebox

With Wilkinson's catalyst; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; hydrogen; potassium acetate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 1432054-82-4
(4S)-3-{(2S)-2-[(S)-[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl]but-3-enoyl}-4-phenyl-1,3-oxazolidin-2-one

: 1432054-91-5
(1R,5S,7aS)-1-(3,5-bis(trifluoromethyl)phenyl)-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine / tetrahydrofuran / 1 h / 20 °C

2: tert.-butylnitrite; hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 2 h / 50 °C

3: Helmchen dibenzo[a,e]cyclooctatetraene (dbcot) iridium phosphoramidite catalyst complex / dichloromethane / 48 h / 33 °C

4: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride / toluene / 2 h / 60 °C / Inert atmosphere

5: Wilkinson's catalyst; hydrogen / ethanol / 2068.65 Torr

6: potassium acetate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / N,N-dimethyl acetamide / 20 h / 80 °C / Glovebox

With hydrogenchloride; Wilkinson's catalyst; tert.-butylnitrite; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; hydrogen; potassium acetate; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; toluene;