(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

Base Information

Chemical Name:(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid
CAS No.:1415336-53-6
Molecular Formula:C₂₃H₃₆N₂O₆Si
Molecular Weight:464.634
Hs Code.:

Synonyms:(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

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Chemical Property of (S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

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Technology Process of (S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

There total 6 articles about (S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₆N₂O₅Si

: 1415336-53-6
(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-49-0
(4R,5R)-5-((R)-but-3-en-2-yl)-4-(2-((tert-butyldimethylsilyl)oxy)ethyl)oxazolidin-2-one

: 1415336-53-6
(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 3.5 h / 0 °C / Inert atmosphere

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: acetonitrile / 4.5 h / 20 °C / Photolysis; Inert atmosphere

5.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / water; 1,4-dioxane; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

6.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; Jones reagent; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-51-4
2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

: 1415336-53-6
(S)-2-((4R,5R)-4-(2-(2-amino-4-((triisopropylsilyl)oxy)phenyl)-2-oxoethyl)-2-oxooxazolidin-5-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 4.5 h / 20 °C / Photolysis; Inert atmosphere

2: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / water; 1,4-dioxane; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

3: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ol303149k