2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

Base Information

Chemical Name:2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide
CAS No.:1415336-51-4
Molecular Formula:C₂₄H₃₈N₂O₄Si
Molecular Weight:446.662
Hs Code.:

Synonyms:2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

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Chemical Property of 2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

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Technology Process of 2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

There total 5 articles about 2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1415336-50-3
2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)acetic acid

: 194869-06-2
3-((triisopropylsilyl)oxy)aniline

: 1415336-51-4
2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

Guidance literature:: 2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)acetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

3-((triisopropylsilyl)oxy)aniline; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-49-0
(4R,5R)-5-((R)-but-3-en-2-yl)-4-(2-((tert-butyldimethylsilyl)oxy)ethyl)oxazolidin-2-one

: 1415336-51-4
2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 3.5 h / 0 °C / Inert atmosphere

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With Jones reagent; tetrabutyl ammonium fluoride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-54-7
tert-butyl [(3R,4R,5R)-1-[(tert-butyldimethylsilyl)oxy]-4-hydroxy-5-methylhept-6-en-3-yl]carbamate

: 1415336-51-4
2-((4R,5R)-5-((R)-but-3-en-2-yl)-2-oxooxazolidin-4-yl)-N-(3-((triisopropylsilyl)oxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

3.1: Jones reagent / acetone / 3.5 h / 0 °C / Inert atmosphere

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

With Jones reagent; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetone; mineral oil;
DOI:10.1021/ol303149k