3-Chloro-6-methoxy-2-methylbenzoic acid

Base Information

• Chemical Name: 3-Chloro-6-methoxy-2-methylbenzoic acid
• CAS No.: 23550-92-7
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.622
• European Community (EC) Number: 843-397-3
• Mol file: 23550-92-7.mol

Synonyms:3-chloro-6-methoxy-2-methylbenzoic acid;23550-92-7;3-chloro-6-methoxy-2-methyl-benzoic acid;MFCD24480938;3-Chloro-6-methoxy-2-methyl-benzoicacid;SCHEMBL7519389;HSYKEWJRHVUDLS-UHFFFAOYSA-N;5-Chloro-2-methoxy-6-methylbenzoic acid;AS-79810;SY322902;CS-0309856;P20619;EN300-7456500;Z1508935039

Chemical Property of 3-Chloro-6-methoxy-2-methylbenzoic acid

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.0240218
• Heavy Atom Count: 13
• Complexity: 195

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1C(=O)O)OC)Cl

Technology Process of 3-Chloro-6-methoxy-2-methylbenzoic acid

There total 4 articles about 3-Chloro-6-methoxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-chloro-6-methoxy-2-methylbenzoate (29237-13-6) → 3-chloro-6-methoxy-2-methylbenzoic acid (23550-92-7)

Guidance literature:

With sodium hydroxide; In methanol; water; for 8h; Inert atmosphere; Reflux;

DOI:10.1039/d0ob01995j

Reference yield:

3-bromo-4-methoxy-2-methylaniline (29237-10-3) → 3-chloro-6-methoxy-2-methylbenzoic acid (23550-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, aq. HCl, (ii) CuCl

2: (i) Mg, Et₂O, (ii) /BRN= 1900390/

DOI:10.1002/hlca.19700530639

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2-Brom-4-chlor-3-methyl-anisol (29237-11-4) → 3-chloro-6-methoxy-2-methylbenzoic acid (23550-92-7)

Guidance literature:

Multistep reaction; (i) Mg, Et₂O, (ii) /BRN= 1900390/;

DOI:10.1002/hlca.19700530639

upstream raw materials:

carbon dioxide

2-Brom-4-chlor-3-methyl-anisol

3-bromo-4-methoxy-2-methylaniline

methyl 3-chloro-6-methoxy-2-methylbenzoate