O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

Base Information

Chemical Name:O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide
CAS No.:105563-15-3
Molecular Formula:C₂₀H₃₂N₂O₅Si
Molecular Weight:408.57
Hs Code.:

Synonyms:O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

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Chemical Property of O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

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Technology Process of O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

There total 2 articles about O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 105563-07-3
N-(benzyloxycarbonyl)-L-serine isoxazolidide

: 105563-15-3
O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1021/jo00376a050

Reference yield:

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

: 105563-15-3
O-(tert-butyldimethylsilyl)-N-(benzyloxycarbonyl)-L-serine isoxazolidide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃, 2.) N-methylmorphiline, isobutyl chloroformate / 1.) THF, water, RT, 3 h, 2.) THF, -15 min, 45 min

2: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

With 4-methyl-morpholine; 1H-imidazole; potassium carbonate; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00376a050