3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Base Information

Chemical Name:3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
CAS No.:1450923-30-4
Molecular Formula:C₂₄H₂₁ClF₃N₅O₄S₂
Molecular Weight:600.042
Hs Code.:

Synonyms:3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

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Chemical Property of 3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

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Technology Process of 3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

There total 5 articles about 3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450923-29-1
4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-3-nitro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

: 1450923-30-4
3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: With iron; acetic acid; In tetrahydrofuran; at 70 ℃; for 1h; Sealed tube;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1450923-30-4
3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 0.75 h

1.2: 2 h / 20 - 34 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.03 h / Cooling with acetone-dry ice

2.2: 20 °C / Cooling with acetone-dry ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

4.1: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

With triisopropoxytitanium(IV) chloride; iron; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1423162-03-1
N-(2,4-dimethoxybenzyl)-4-fluoro-3-nitro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

: 1450923-30-4
3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

With iron; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran;