4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Base Information

Chemical Name:4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide
CAS No.:1450923-38-2
Molecular Formula:C₂₈H₂₅ClF₃N₅O₅S₂
Molecular Weight:668.117
Hs Code.:

Synonyms:4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

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Chemical Property of 4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

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Technology Process of 4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

There total 7 articles about 4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450923-31-5
1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

: 108-24-7
acetic anhydride

: 1450923-38-2
4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 70 ℃; for 2.5h;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1450923-38-2
4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.03 h / Cooling with acetone-dry ice

1.2: 20 °C / Cooling with acetone-dry ice

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

3.1: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

4.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 20 - 70 °C

With iron; sodium hydride; caesium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1450923-38-2
4-acetyl-1-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 0.75 h

1.2: 2 h / 20 - 34 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.03 h / Cooling with acetone-dry ice

2.2: 20 °C / Cooling with acetone-dry ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

4.1: acetic acid; iron / tetrahydrofuran / 1 h / 70 °C / Sealed tube

5.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 20 - 70 °C

With triisopropoxytitanium(IV) chloride; iron; sodium hydride; caesium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;