C₂₁H₂₆O₅

Base Information

• Chemical Name: C₂₁H₂₆O₅
• CAS No.: 106569-73-7
• Molecular Formula: C₂₁H₂₆O₅
• Molecular Weight: 358.434
• Mol file: 106569-73-7.mol

Synonyms:C₂₁H₂₆O₅

Chemical Property of C₂₁H₂₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆O₅

There total 22 articles about C₂₁H₂₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C20H24O5 (106569-72-6) + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → C21H26O5 (106569-73-7)

Guidance literature:

In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃; for 1.75h;

Reference yield:

5-octynolic acid (76469-08-4) → C21H26O5 (106569-73-7)

Guidance literature:

Multi-step reaction with 16 steps

1: (COCl)2

2: 1) nBuLi / 1) THF

3: 1) (Me₂Si)2NLi / 1) THF, -78 deg C, 2) THF, -78 to 0 deg C

4: LiAlH₄ / tetrahydrofuran

5: KH / tetrahydrofuran

6: 1) ozone

7: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO₃ / hexane

8: Me₂AlCl / CH₂Cl₂

10: ozone

11: 1) t-BuLi / 1) THF, 2) THF, HMPA

12: H₃O⁽¹⁺⁾

13: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, 2) -78 to -10 deg C

14: ZnBr₂ / CH₂Cl₂

15: CSA / benzene

16: 79 percent / tetrahydrofuran; dimethylsulfoxide

With quinoline; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; (Me₂Si)2NLi; camphor-10-sulfonic acid; oxonium; hydrogen; tert.-butyl lithium; dimethylaluminum chloride; potassium hydride; ozone; dimethyl sulfoxide; triethylamine; zinc dibromide; Lindlar's catalyst; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; benzene;

DOI:10.1021/ja00238a060

Reference yield:

benzyl bromide (100-39-0) → C21H26O5 (106569-73-7)

Guidance literature:

Multi-step reaction with 12 steps

1: KH / tetrahydrofuran

2: 1) ozone

3: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO₃ / hexane

4: Me₂AlCl / CH₂Cl₂

6: ozone

7: 1) t-BuLi / 1) THF, 2) THF, HMPA

8: H₃O⁽¹⁺⁾

9: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, 2) -78 to -10 deg C

10: ZnBr₂ / CH₂Cl₂

11: CSA / benzene

12: 79 percent / tetrahydrofuran; dimethylsulfoxide

With quinoline; oxalyl dichloride; camphor-10-sulfonic acid; oxonium; hydrogen; tert.-butyl lithium; dimethylaluminum chloride; potassium hydride; ozone; dimethyl sulfoxide; triethylamine; zinc dibromide; Lindlar's catalyst; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; benzene;

DOI:10.1021/ja00238a060

upstream raw materials:

C₂₀H₂₄O₅

dimethylsulfoxonium methylide

Tetrahydro-4H-pyran-4-one

5-octynolic acid

Downstream raw materials:

C₂₄H₃₄O₅Si

C₂₄H₃₄O₅Si

C₂₆H₃₁F₃O₈

C₂₆H₃₁F₃O₈