(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

Base Information

Chemical Name:(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol
CAS No.:852661-60-0
Molecular Formula:C₁₅H₂₂F₄N₂O
Molecular Weight:322.346
Hs Code.:

Synonyms:(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

Chemical Property:

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Technology Process of (2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

There total 8 articles about (2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-59-7
(2S,3R)-3-(dibenzylamino)-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

: 852661-60-0
(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; In methanol;
DOI:10.1016/j.bmcl.2007.11.087

Reference yield:

: 852661-58-6
[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amine

: 852661-60-0
(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 96 h / 25 °C / Heating / reflux

2: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 72 h / 2585.81 Torr

With hydrogen; palladium dihydroxide; In methanol; ethanol; ethyl acetate;

Reference yield:

: 852661-57-5
3-(4-fluorophenyl)-N-(2,2,2-trifluoroethyl)propanamide

: 852661-60-0
(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.17 h / 25 °C / Heating / reflux

2: ethanol / 96 h / 25 °C / Heating / reflux

3: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 72 h / 2585.81 Torr

With lithium aluminium tetrahydride; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate;