N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852661-56-4
Molecular Formula:C₂₄H₂₉F₄N₇O₂
Molecular Weight:523.534
Hs Code.:

Synonyms:N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Chemical Property of N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Technology Process of N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 10 articles about N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-60-0
(2S,3R)-3-amino-1-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]butan-2-ol

: 382637-78-7
[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester

: 852661-56-4
N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: In acetonitrile; at 25 ℃;

Reference yield:

: 852661-58-6
[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amine

: 852661-56-4
N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 96 h / 25 °C / Heating / reflux

2: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 72 h / 2585.81 Torr

3: acetonitrile / 25 °C

With hydrogen; palladium dihydroxide; In methanol; ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 852661-57-5
3-(4-fluorophenyl)-N-(2,2,2-trifluoroethyl)propanamide

: 852661-56-4
N-{(1R,2S)-3-[[3-(4-fluorophenyl)propyl](2,2,2-trifluoroethyl)amino]-2-hydroxy-1-methylpropyl}-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.17 h / 25 °C / Heating / reflux

2: ethanol / 96 h / 25 °C / Heating / reflux

3: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 72 h / 2585.81 Torr

4: acetonitrile / 25 °C

With lithium aluminium tetrahydride; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; acetonitrile;