diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Base Information

Chemical Name:diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate
CAS No.:1441049-01-9
Molecular Formula:C₂₀H₁₈F₂N₂O₄
Molecular Weight:388.371
Hs Code.:

Synonyms:diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

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Chemical Property of diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

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Technology Process of diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

There total 2 articles about diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 2521-99-5
2-(4-fluorophenylamino)acetic acid ethyl ester

: 1441049-01-9
diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Guidance literature:: With oxygen; tris(p-bromophenylammoniumyl) hexachloroantimonate; In acetonitrile; at 60 ℃; for 24h;
DOI:10.1016/j.tetlet.2016.11.052

Reference yield:

: 371-40-4
4-fluoroaniline

: 1441049-01-9
diethyl 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 85 - 90 °C

2: 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; iron(II) triflate / 1,2-dichloro-ethane / 24 h / 60 °C / Sealed tube; Inert atmosphere

With iron(II) triflate; sodium acetate; 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jo4007199