(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

Base Information

Chemical Name:(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate
CAS No.:937057-93-7
Molecular Formula:C₂₆H₂₇ClN₄O₆S
Molecular Weight:559.043
Hs Code.:

Synonyms:(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

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Chemical Property of (1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

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Technology Process of (1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

There total 12 articles about (1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 937057-91-5
(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methanol

: 124-63-0
methanesulfonyl chloride

: 937057-93-7
(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; Cooling with ice;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937057-93-7
(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 12 steps

1.1: trichlorophosphate / 20 °C / Cooling with ice

1.2: 3 h / 50 °C

2.1: toluene / 7 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

5.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

9.1: toluene / Reflux

10.1: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

11.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

12.1: triethylamine / dichloromethane / Cooling with ice

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1.1: Vilsmeier reaction / 1.2: Vilsmeier reaction / 2.1: Wittig reaction / 4.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937057-93-7
(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 11 steps

1: toluene / 7 h / 100 °C

2: sodium tetrahydroborate / methanol / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6: triethylamine / dichloromethane / 3 h / 0 °C

7: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

8: toluene / Reflux

9: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

10: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

11: triethylamine / dichloromethane / Cooling with ice

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: Wittig reaction / 3: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054