3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Base Information

Chemical Name:3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide
CAS No.:1309365-91-0
Molecular Formula:C₃₁H₃₇N₅O₂
Molecular Weight:511.667
Hs Code.:

Synonyms:3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

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Chemical Property of 3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

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Technology Process of 3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

There total 7 articles about 3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 693-98-1
2-methylimidazole

: 1309365-87-4
3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-N-(cyclohexylmethyl)propanamide

: 1309365-91-0
3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: With caesium carbonate; Hippuric Acid; copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 140 ℃; for 48h; sealed tube;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1309365-91-0
3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2.1: ethanol / 2.5 h / 125 °C / Sealed tube

3.1: tetrahydrofuran / 2.5 h / 70 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

4.2: pH ~ 1

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

6.1: hydrogen / platinum on carbon / ethanol / 18 h

7.1: caesium carbonate / copper(II) acetate monohydrate; Hippuric Acid / N,N-dimethyl-formamide / 48 h / 140 °C / sealed tube

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; Hippuric Acid; platinum on carbon; copper(II) acetate monohydrate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1309365-91-0
3-(2-(4-methoxybenzylamino)-6-(2-methyl-1H-imidazol-1-yl)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 2.5 h / 125 °C / Sealed tube

2.1: tetrahydrofuran / 2.5 h / 70 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

3.2: pH ~ 1

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

5.1: hydrogen / platinum on carbon / ethanol / 18 h

6.1: caesium carbonate / copper(II) acetate monohydrate; Hippuric Acid / N,N-dimethyl-formamide / 48 h / 140 °C / sealed tube

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; Hippuric Acid; platinum on carbon; copper(II) acetate monohydrate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; N,N-dimethyl-formamide;