Technology Process of octanoic acid, (+/-)-5,5-difluoro-4-oxo-2-<<oxy>methyl>undecyl ester
There total 13 articles about octanoic acid, (+/-)-5,5-difluoro-4-oxo-2-<<oxy>methyl>undecyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dipyridine chromium trioxide;
In
dichloromethane;
DOI:10.1021/ja00260a020
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH2Cl2 / 2.5 h
2: 27 percent / tert-butyllithium / diethyl ether / 1.) -78 deg C, 12 min; 2.) 15 min
3: 87 percent / 1N HCl / tetrahydrofuran / Ambient temperature
4: 80 percent / pyridine / CHCl3 / 1.) 0 deg C, 30 min; 2.) RT
5: 100 percent / NaBH4 / ethanol / 0.5 h / Ambient temperature
6: 87 percent / pyridine / Ambient temperature
7: 74 percent / CrO3(pyridine)2 / CH2Cl2
With
pyridine; hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; tert.-butyl lithium; dipyridine chromium trioxide; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform;
DOI:10.1021/ja00260a020
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 72 percent / 4 h / Heating
2: 82 percent / LiAlH4
3: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH2Cl2 / 2.5 h
4: 27 percent / tert-butyllithium / diethyl ether / 1.) -78 deg C, 12 min; 2.) 15 min
5: 87 percent / 1N HCl / tetrahydrofuran / Ambient temperature
6: 80 percent / pyridine / CHCl3 / 1.) 0 deg C, 30 min; 2.) RT
7: 100 percent / NaBH4 / ethanol / 0.5 h / Ambient temperature
8: 87 percent / pyridine / Ambient temperature
9: 74 percent / CrO3(pyridine)2 / CH2Cl2
With
pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; tert.-butyl lithium; dipyridine chromium trioxide; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform;
DOI:10.1021/ja00260a020
