51335-75-2

Basic information

• Product Name: NSC 693437
• Synonyms: 2,2-Dimethyl-5,5-dicarbethoxy-1,3-dioxane;NSC 147806;NSC 693437;2, 2-DiMethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid, diethyl ester;2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid diethyl ester
• CAS NO: 51335-75-2
• Molecular Formula: C₁₂H₂₀O₆
• Molecular Weight: 260.2836
• Mol File: 51335-75-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 276℃
• Flash Point: 113℃
• Appearance: /
• Density: 1.114
• Vapor Pressure: 0.00503mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: 2-8°C
• CAS DataBase Reference: NSC 693437(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 693437(51335-75-2)
• EPA Substance Registry System: NSC 693437(51335-75-2)

Safety Data

• Hazardous Substances Data: 51335-75-2(Hazardous Substances Data)

Usage

General Description

NSC 693437, also known as 3,3',5,5'-tetrabromobisphenol A, is a chemical compound that belongs to the class of brominated flame retardants. It is commonly used in the production of plastics, resins, and thermal paper as a flame retardant additive. This chemical is known to have endocrine disrupting properties, as well as potential toxic effects on the reproductive and developmental systems. NSC 693437 has been studied for its environmental impact and has been found to be persistent and bioaccumulative in the environment, posing a potential risk to human and ecological health. As a result, there are increasing concerns about the use and exposure to this chemical, leading to efforts to find safer alternatives for flame retardant applications.

InChI:InChI=1/C12H20O6/c1-5-15-9(13)12(10(14)16-6-2)7-17-11(3,4)18-8-12/h5-8H2,1-4H3

Upstream product

• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 105-53-3 diethyl malonate 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 10029-04-6 ethyl 2-(hydroxymethyl)acrylate 
• 82962-54-7 2,2-dimethyl-5-ethoxycarbonyl-1,3-dioxane 
• 239089-28-2 5-Formyl-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 239089-27-1 9-(4-methoxyphenyl)-3,3-dimethyl-2,4,8,10-tetraoxaspiro[5.5]undecane 
• 239089-26-0 (5-(((4-methoxybenzyl)oxy)methyl)-2,2-dimethyl-1,3-dioxan-5-yl)methanol 
• 239089-29-3 (1'R)-5-(1'-Hydroxybut-3'-enyl)-5-p-methoxybenzyloxymethyl-2,2-dimethyl-5-(1'-trimethylsilyloxybut-3'-enyl)-1,3-dioxane 
• 239089-25-9 5,5-Bis(p-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxane 
• 239089-32-8 (1'R,3'S)-5-{1',3'-Dihydroxy-3'-[furan-2''(5''H)-on-4''-yl]propyl}-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 239089-33-9 (1'R,3'S)-5-{1',3'-Bistriethylsilyloxy-3'-[furan-2''(5''H)-on-4''-yl]propyl}-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 4728-12-5 2,2-dimethyl-5-hydroxymethyl-1,3-dioxane 
• 97827-17-3 5-iodomethyl-2,2-dimethyl-1,3-dioxane 
• 133384-73-3 5-(toluenesulfonyloxymethyl)-2,2-dimethyl-1,3-dioxane 
• 113002-29-2 R_S-1-methyl-2-(2,2-dimethyl-1,2-dioxolanyl)-2-p-tolylsulfinyl-1-ethanone 
• 111935-01-4 octanoic acid, (+/-)-5,5-difluoro-4-oxo-2-<<oxy>methyl>undecyl ester 

Relevant articles and documents

Rhodium-Catalyzed Cyclization of O,ω-Unsaturated Alkoxyamines: Formation of Oxygen-Containing Heterocycles

O,ω-Unsaturated N-tosyl alkoxyamines undergo unexpected RhIII-catalyzed intramolecular cyclization by oxyamination to produce oxygen-containing heterocycles. Mechanistic studies show that an aziridine intermediate seems to be responsible for the formation of the heterocycles, possibly via a RhV species.

Synthesis of Panal Terpenoid Core

Panal is a natural bicyclic cadalane-type sesquiterpenoid with an unusual combination of stereocenters. It was isolated in 1988 as an alleged biosynthetic precursor of luciferin (a light-emitting molecule) in a bioluminescent fungus Panellus stipticus. Herein we present the first approach to the synthesis of the terpenoid skeleton of panal, which includes construction of five stereocenters, one of which is easily epimerizable. The key steps in the synthetic approach presented are high-pressure Diels-Alder reaction disobeying the ‘endo rule’, Barbier reductive allylation, and cyclization of trans-decalin ring via ring-closing metathesis.

METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS

The invention features methods and compositions for the synthesis of multimerizing agents.