ethyl 1,1-dimethyl-3-phenylpropargyl acetate

Base Information

• Chemical Name: ethyl 1,1-dimethyl-3-phenylpropargyl acetate
• CAS No.: 61423-02-7
• Molecular Formula: C₁₃H₁₄O₂
• Molecular Weight: 202.253
• Mol file: 61423-02-7.mol

Synonyms:ethyl 1,1-dimethyl-3-phenylpropargyl acetate

Chemical Property of ethyl 1,1-dimethyl-3-phenylpropargyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1,1-dimethyl-3-phenylpropargyl acetate

There total 7 articles about ethyl 1,1-dimethyl-3-phenylpropargyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetic anhydride (108-24-7) + phenylacetylene (536-74-3) + acetone (67-64-1) → ethyl 1,1-dimethyl-3-phenylpropargyl acetate (61423-02-7)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

acetone; In tetrahydrofuran; hexane; at 20 ℃; for 2h; Inert atmosphere;

acetic anhydride; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c8ob00781k

Reference yield: 69.0%

2-Methyl-4-phenyl-3-butyn-2-ol (1719-19-3) + acetic anhydride (108-24-7) → ethyl 1,1-dimethyl-3-phenylpropargyl acetate (61423-02-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1039/c7cc01759f

Reference yield: 60.0%

3-methyl-1-phenyl-but-1-yne (1612-03-9) + acetone (67-64-1) → ethyl 1,1-dimethyl-3-phenylpropargyl acetate (61423-02-7)

Guidance literature:

3-methyl-1-phenyl-but-1-yne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

acetone; In tetrahydrofuran; hexane; at 20 ℃; for 2h; Inert atmosphere;

In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.jorganchem.2018.06.020

upstream raw materials:

Ketene

2-Methyl-4-phenyl-3-butyn-2-ol

acetic anhydride

acetyl chloride

Downstream raw materials:

3-acetoxy-3-methyl-1-phenyl-butane-1,2-dione

(3,3-dimethyl-but-1-ynyl)benzene

(3,3-dimethylhex-5-en-1-yn-1-yl)benzene