3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

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Chemical Name:3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester
CAS No.:1063992-92-6
Molecular Formula:C₂₃H₂₄F₂N₂O₅S
Molecular Weight:478.517
Hs Code.:

Synonyms:3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

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Technology Process of 3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

There total 3 articles about 3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1063992-91-5
1-(4-difluoromethoxybenzenesulfonyl)-5-iodo-1H-indole

: 147621-21-4
tert-butyl azetidine-1-carboxylate

: 1063992-92-6
3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl azetidine-1-carboxylate; With chloro-trimethyl-silane; ethylene dibromide; zinc; In ISOPROPYLAMIDE; at 20 - 65 ℃; for 0.5h;

1-(4-difluoromethoxybenzenesulfonyl)-5-iodo-1H-indole; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ISOPROPYLAMIDE; at 80 ℃; for 1h;

Reference yield:

: 351003-34-4
4-[(difluoromethyl)oxy]benzenesulfonyl chloride

: 1063992-92-6
3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0.75 h

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / ISOPROPYLAMIDE / 0.5 h / 20 - 65 °C

2.2: 1 h / 80 °C

With chloro-trimethyl-silane; sodium hydride; ethylene dibromide; zinc; In ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 16066-91-4
5-iodo-1H-indole

: 1063992-92-6
3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0.75 h

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / ISOPROPYLAMIDE / 0.5 h / 20 - 65 °C

2.2: 1 h / 80 °C

With chloro-trimethyl-silane; sodium hydride; ethylene dibromide; zinc; In ISOPROPYLAMIDE; N,N-dimethyl-formamide;