1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

Base Information

Chemical Name:1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride
CAS No.:1063993-07-6
Molecular Formula:C₂₁H₂₂F₂N₂O₃S*ClH
Molecular Weight:456.941
Hs Code.:

Synonyms:1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

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Chemical Property of 1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

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Technology Process of 1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

There total 4 articles about 1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1063993-08-7
5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole

: 123-38-6
propionaldehyde

: 1063993-07-6
1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

Guidance literature:: 5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole; propionaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; for 0.166667h;

With hydrogenchloride;

Reference yield:

: 1063992-92-6
3-[1-(4-difluoromethoxy-benzenesulfonyl)-1H-indol-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

: 1063993-07-6
1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.17 h

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 351003-34-4
4-[(difluoromethyl)oxy]benzenesulfonyl chloride

: 1063993-07-6
1-(4-difluoromethoxy-benzenesulfonyl)-5-(1-propyl-azetidin-3-yl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0.75 h

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / ISOPROPYLAMIDE / 0.5 h / 20 - 65 °C

2.2: 1 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.17 h

With chloro-trimethyl-silane; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; ethylene dibromide; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;