<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

Base Information

Chemical Name:<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one
CAS No.:95935-96-9
Molecular Formula:C₂₆H₄₄O₄Si
Molecular Weight:448.718
Hs Code.:

<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benz<e>inden-7-one

Synonyms:<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

Suppliers and Price of <3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of <3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

There total 1 articles about <3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29021-98-5
3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol

: 95935-96-9
<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating

2: 96 percent / p-TsOH / benzene / 5 h / Heating

3: 32 percent / Na / diethyl ether; dimethylformamide / 1 h / 95 °C

4: 1.) BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 4 h, b) 20 deg C, 12 h

With n-butyllithium; chloro-trimethyl-silane; sodium; toluene-4-sulfonic acid; lithium bromide; In diethyl ether; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/jlcr.2580360806

Reference yield:

: 95935-96-9
<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

: 5173-46-6
4,9-Androstadiene-3,17-dione

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C

2: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4: Jones reagent / acetone / 0 °C

With Jones reagent; potassium tert-butylate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol; 4: |Jones Oxidation;

Reference yield:

: 95935-96-9
<3aS-(3aα,9aα,9bβ)>-3β-((tert-butyldimethylsilyl)oxy)-3aβ-methyl-6-<2-(2-methyl-1,3-dioxolan-2-yl)ethyl>-1,2,3,3a,4,5,8,9,9a,9b-decahydro-7H-benzinden-7-one

: 6218-29-7
17β-hydroxyestra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C

2: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol;