6218-29-7Relevant articles and documents
Preparation method of estra-4,9-diene-3,17-dione
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, (2018/05/30)
The invention relates to the technical field of processing pharmaceutical intermediates, and particularly relates to a preparation method of estra-4,9-diene-3,17-dione. The method comprises the following steps: (1) carbonyl reduction reaction; (2) hydroxyl protection reaction; (3) substitution reaction; (4) double bond reduction reaction; (5) ketal hydrolysis reaction; (6) cyclization reaction; (7) substitution reaction; (8) ketal hydrolysis reaction; (9) cyclization reaction; (10) hydroxyl deprotection reaction; and (11) hydroxyl oxidation reaction. Reagents used in the method are light in environmental pollution and meet requirements of green chemistry; required raw materials are simple, and easily available and can facilitate industrial production; and the route is simple, the operationis easy, and the control is easy.
A simple method for the small scale synthesis and solid-phase extraction purification of steroid sulfates
Waller, Christopher C.,McLeod, Malcolm D.
supporting information, p. 74 - 80 (2015/02/19)
Steroid sulfates are a major class of steroid metabolite that are of growing importance in fields such as anti-doping analysis, the detection of residues in agricultural produce or medicine. Despite this, many steroid sulfate reference materials may have limited or no availability hampering the development of analytical methods. We report simple protocols for the rapid synthesis and purification of steroid sulfates that are suitable for adoption by analytical laboratories. Central to this approach is the use of solid-phase extraction (SPE) for purification, a technique routinely used for sample preparation in analytical laboratories around the world. The sulfate conjugates of sixteen steroid compounds encompassing a wide range of steroid substitution patterns and configurations are prepared, including the previously unreported sulfate conjugates of the designer steroids furazadrol (17β-hydroxyandrostan[2,3-d]isoxazole), isofurazadrol (17β-hydroxyandrostan[3,2-c]isoxazole) and trenazone (17β-hydroxyestra-4,9-dien-3-one). Structural characterization data, together with NMR and mass spectra are reported for all steroid sulfates, often for the first time. The scope of this approach for small scale synthesis is highlighted by the sulfation of 1 μg of testosterone (17β-hydroxyandrost-4-en-3-one) as monitored by liquid chromatography-mass spectrometry (LCMS).
Antiglucocorticoid steroids for the treatment of anxiety disorders
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, (2008/06/13)
The invention relates to the use of antiglucocorticoid steroids for the manufacture of a pharmaceutical composition for the treatment of anxiety disorders.
