tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate
CAS No.:494783-53-8
Molecular Formula:C₃₀H₄₀ClN₃O₅S
Molecular Weight:590.184
Hs Code.:

Synonyms:tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

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Chemical Property of tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

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Technology Process of tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

There total 7 articles about tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 494783-51-6
(2S)-3-[(tert-Butyl)-oxycarbonyl]-2-[(4-chlorophenyl)methyl]-propanoic acid

: 494783-46-9
N-cyclopropylmethyl-N-(2-piperazin-1-yl-phenyl)-methanesulfonamide

: 494783-53-8
tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2003.10.056

Reference yield:

: N-(cyclopropylmethyl)-(methylsulfonyl)(2-piperazinylphenyl)amine

: 494783-51-6
(2S)-3-[(tert-Butyl)-oxycarbonyl]-2-[(4-chlorophenyl)methyl]-propanoic acid

: 494783-53-8
tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

Guidance literature:: With triethanolamine; sodium hydrogencarbonate; benzotriazol-1-ol; 1,2-dichloro-ethane; In hexane; dichloromethane; ethyl acetate;

Reference yield:

: 199105-18-5
N-[2-(4-Benzyl-piperazin-1-yl)-phenyl]-methanesulfonamide

: 494783-53-8
tert-butyl (3S)-3-[(4-chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)-amino]phenyl}-piperazinyl)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaH / dimethylformamide

2: 100 percent / H₂ / Pd/C / ethyl acetate

3: 90 percent / EDC; HOAt; Et₃N / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.10.056