tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate
CAS No.:494783-55-0
Molecular Formula:C₃₅H₄₈ClN₅O₆S
Molecular Weight:702.315
Hs Code.:

tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

Synonyms:tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

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Chemical Property of tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

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Technology Process of tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

There total 6 articles about tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 494783-54-9
(3S)-3-[(4-Chlorophenyl)-methyl]-4-(4-{2-[(cyclopropylmethyl)-(methylsulfonyl)-amino]phenyl}piperazinyl)-4-oxobutanoic acid

: 494783-55-0
tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2003.10.056

Reference yield:

: 199105-18-5
N-[2-(4-Benzyl-piperazin-1-yl)-phenyl]-methanesulfonamide

: 494783-55-0
tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaH / dimethylformamide

2: 100 percent / H₂ / Pd/C / ethyl acetate

3: 90 percent / EDC; HOAt; Et₃N / CH₂Cl₂

4: 100 percent / trifluoroacetic acid / CH₂Cl₂

5: EDC; HOAt / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.10.056

Reference yield:

: 678995-20-5
N-[2-(4-benzyl-piperazin-1-yl)-phenyl]-N-cyclopropylmethyl-methanesulfonamide

: 494783-55-0
tert-butyl 4-[(3S)-3-[(4-chlorophenyl)methyl]-4-(4-{2-[(cyclopropylmethyl)(methylsulfonyl)amino]-phenyl}piperazinyl)-4-oxobutanoyl]piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate

2: 90 percent / EDC; HOAt; Et₃N / CH₂Cl₂

3: 100 percent / trifluoroacetic acid / CH₂Cl₂

4: EDC; HOAt / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2003.10.056