(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

Base Information

Chemical Name:(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine
CAS No.:1257229-78-9
Molecular Formula:C₁₅H₁₅F₄N₃O₂S₂
Molecular Weight:409.429
Hs Code.:

Synonyms:(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

Suppliers and Price of (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

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Technology Process of (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

There total 1 articles about (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 100481-09-2
thiazole-2-sulfonyl chloride

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine: 946399-84-4,1414960-67-0
(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

: 1257229-78-9
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3.25h;

Reference yield: 64.4%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1257229-78-9
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

: 1257229-79-0
methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

Guidance literature:: (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

methyl 3,3,3-trifluoropyruvate; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;