methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

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Chemical Name:methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate
CAS No.:1257229-79-0
Molecular Formula:C₁₉H₁₈F₇N₃O₅S₂
Molecular Weight:565.49
Hs Code.:

Synonyms:methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

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Chemical Property of methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

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Technology Process of methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

There total 2 articles about methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.4%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1257229-78-9
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine

: 1257229-79-0
methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

Guidance literature:: (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1,3-thiazol-2-ylsulfonyl)piperazine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

methyl 3,3,3-trifluoropyruvate; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1415042-11-3
C₁₅H₁₄BrF₄N₃O₂S₂

: 1257229-79-0
methyl 3,3,3-trifluoro-2-[2-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-1,3-thiazol-5-yl]-2-hydroxypropanoate

Guidance literature:: C₁₅H₁₄BrF₄N₃O₂S₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

methyl 3,3,3-trifluoropyruvate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/ml300352x