Technology Process of (1R,2S)-2-(tetrahydropyranyloxy)cyclohexanol
There total 5 articles about (1R,2S)-2-(tetrahydropyranyloxy)cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / tetrahydrofuran / 0.5 h / 0 °C
2: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH2Cl2 / 22 h / -40 °C
3: 97 percent Spectr. / TiCl4 / CH2Cl2 / 1 h / -85 °C
4: 1.) pyridinium p-toluenesulfonate (PTS), 2.) t-BuOK / 1.) CH2Cl2. room temperature, 40 h, 2.) t-BuOH, 60 deg C, 2 h
With
trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; pyridinium p-toluenesulfonate; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00272a027
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH2Cl2 / 22 h / -40 °C
2: 97 percent Spectr. / TiCl4 / CH2Cl2 / 1 h / -85 °C
3: 1.) pyridinium p-toluenesulfonate (PTS), 2.) t-BuOK / 1.) CH2Cl2. room temperature, 40 h, 2.) t-BuOH, 60 deg C, 2 h
With
trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; pyridinium p-toluenesulfonate; titanium tetrachloride;
In
dichloromethane;
DOI:10.1021/jo00272a027
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent Spectr. / TiCl4 / CH2Cl2 / 1 h / -85 °C
2: 1.) pyridinium p-toluenesulfonate (PTS), 2.) t-BuOK / 1.) CH2Cl2. room temperature, 40 h, 2.) t-BuOH, 60 deg C, 2 h
With
potassium tert-butylate; pyridinium p-toluenesulfonate; titanium tetrachloride;
In
dichloromethane;
DOI:10.1021/jo00272a027
