4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

Base Information

Chemical Name:4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a
CAS No.:86635-15-6
Molecular Formula:C₆₄H₈₄O₁₉
Molecular Weight:1157.36
Hs Code.:

4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B<sub>1</sub>a

Synonyms:4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

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Chemical Property of 4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

Chemical Property:

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Technology Process of 4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

There total 4 articles about 4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 144367-88-4
4a-O-(tert-Butyldimethylsilyl)-5,4''-di-O-phenoxyacetyl-avermectin B₁a

: 86635-15-6
4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

Guidance literature:: With hydrogen fluoride; In tetrahydrofuran; pyridine; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)89865-3

Reference yield:

: 65195-55-3
avermectin B₁a

: 86635-15-6
4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / SeO₂, tBuOOH / CH₂Cl₂ / 14 h / Ambient temperature

2: 95 percent / NEt₃, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 8 h / Ambient temperature

3: 98 percent / 4-dimethylaminopyridine (DMAP) / pyridine / 3 h / Ambient temperature

4: 80 percent / HF / pyridine; tetrahydrofuran / 2 h / Ambient temperature

With tert.-butylhydroperoxide; dmap; selenium(IV) oxide; hydrogen fluoride; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)89865-3

Reference yield:

: 86629-72-3
4a-hydroxyavermectin B₁

: 86635-15-6
4a-Hydroxy-5,4''-di-O-phenoxyacetyl-avermectin B₁a

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NEt₃, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 8 h / Ambient temperature

2: 98 percent / 4-dimethylaminopyridine (DMAP) / pyridine / 3 h / Ambient temperature

3: 80 percent / HF / pyridine; tetrahydrofuran / 2 h / Ambient temperature

With dmap; hydrogen fluoride; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)89865-3