(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Base Information

Chemical Name:(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate
CAS No.:1415635-86-7
Molecular Formula:C₄₃H₆₆O₈Si
Molecular Weight:739.078
Hs Code.:

(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Synonyms:(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Suppliers and Price of (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

There total 15 articles about (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415635-75-4
(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2,4-dimethoxy-6-((S)-3-methyl-2-oxopent-4-en-1-yl)benzoate

: 1415635-86-7
(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

: (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2S,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Guidance literature:: With Noyori's catalyst; sodium formate; In water; N,N-dimethyl-formamide; at 40 ℃; for 36h; Overall yield = 98%; Overall yield = 108 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302999v

Reference yield:

: 1415635-82-3
(2S,3R,4R,Z)-3-hydroxy-N-methoxy-8-((4-methoxybenzyl)oxy)-N,2,4-trimethyloct-6-enamide

: 1415635-86-7
(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

: (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2S,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

3.1: diethyl ether / 3 h / -78 °C / Inert atmosphere

3.2: 4 h / Inert atmosphere; Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 - 20 °C / Inert atmosphere

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

5.2: 0.17 h / -78 °C / Inert atmosphere

6.1: sodium formate; Noyori's catalyst / water; N,N-dimethyl-formamide / 36 h / 40 °C / Inert atmosphere

With 2,6-dimethylpyridine; Noyori's catalyst; sodium formate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol302999v

Reference yield:

: 277297-37-7
(2S)-N-[1R,2R]-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethyl-4-pentenamide

: 1415635-86-7
(4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

: (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2S,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydroxide / tert-butyl alcohol; water / 23 h / 50 °C / Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

4.1: sodium formate; Noyori's catalyst / water; N,N-dimethyl-formamide / 36 h / 40 °C / Inert atmosphere

With Noyori's catalyst; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; tetra(n-butyl)ammonium hydroxide; sodium formate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol302999v