tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Name:tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate
CAS No.:1165799-37-0
Molecular Formula:C₃₃H₄₉N₅O₄
Molecular Weight:579.783
Hs Code.:

tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Synonyms:tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Property of tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Technology Process of tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

There total 8 articles about tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 205596-29-8
4-nitrophenyl (tetrahydro-2H-pyran-4-yl)carbonate

: C₂₇H₄₁N₅O*ClH

: 1165799-37-0
tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 40 ℃; for 19h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1165799-37-0
tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 19 h / 20 - 40 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165799-02-9
tert-butyl [(trans-4-{[({2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate

: 1165799-37-0
tetrahydro-2H-pyran-4-yl {[trans-4-({[(2-{4-[2-(di-methylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

3: hydrogenchloride; water / 1,4-dioxane / 0.25 h / 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 19 h / 20 - 40 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.04.014