tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate
CAS No.:1165799-06-3
Molecular Formula:C₃₂H₄₉N₅O₃
Molecular Weight:551.773
Hs Code.:

Synonyms:tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Property of tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Technology Process of tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

There total 5 articles about tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1165800-29-2
C₃₁H₄₆N₄O₆S

: 124-40-3
dimethyl amine

: 1165799-06-3
tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: In methanol; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165799-02-9
tert-butyl [(trans-4-{[({2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate

: 1165799-06-3
tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165797-46-5
tert-butyl {[trans-4-({[(2-chloroquinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

: 1165799-06-3
tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.04.014