Technology Process of ADB-FUBINACA
There total 6 articles about ADB-FUBINACA which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 18 - 25 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 18 - 25 °C / 3040.2 Torr
2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C
With
hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice
1.2: 5 h / 0 - 20 °C
2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C
With
potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
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