2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine

Base Information

• Chemical Name: 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine
• CAS No.: 948048-03-1
• Molecular Formula: C₅₀H₃₉F₆N₅O₈S₂
• Molecular Weight: 1016.01
• Mol file: 948048-03-1.mol

Synonyms:2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine

Chemical Property of 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine

There total 5 articles about 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

trifluoromethylsulfonic anhydride (358-23-6) + (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9) → 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine (948048-03-1) + C49H40F3N5SO6

Guidance literature:

With dmap; In pyridine; at 0 - 20 ℃; for 3.5h;

DOI:10.1002/chem.200700058

Reference yield: 53.0%

trifluoromethane sulfonyl chloride (421-83-0) + (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9) → 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine (948048-03-1) + C49H39F3N5SO5Cl + C49H38F3N5SO5 + C49H40F3N5SO6

Guidance literature:

With pyridine; dmap;

DOI:10.1002/chem.200700058

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9) → 2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine (948048-03-1)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃; for 3.5h;

upstream raw materials:

trifluoromethane sulfonyl chloride

(2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol

trifluoromethylsulfonic anhydride

trityl chloride

Downstream raw materials:

9-(2',3'-anhydro-6-N,5'-O-ditrityl-β-D-lyxofuranosyl)adenine

9-(3'-azido-3'-deoxy-6-N,5'-O-ditrityl-β-D-arabinofuranosyl)adenine

3'-[(2-N-tert-butoxycarbonyl-O-methyl)-L-tyrosyl]amido-2',3'-dideoxy-2'-fluoro-6-N,5'-O-ditrityladenosine

2'-azido-2',3'-dideoxy-3'-fluoro-6-N,5'-O-ditrityladenosine