N,5'-O-Ditrityladenosine

Base Information

• Chemical Name: N,5'-O-Ditrityladenosine
• CAS No.: 31085-55-9
• Molecular Formula: C48H41 N5 O4
• Molecular Weight: 751.885
• Mol file: 31085-55-9.mol

Synonyms:Adenosine,N-trityl-5'-O-trityl- (6CI,8CI); N6-Trityl-5'-O-trityladenosine; NSC 14168

Chemical Property of N,5'-O-Ditrityladenosine

Chemical Property:

• PSA: 114.55000
• Density: 1.26g/cm³
• LogP: 7.93120

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,5'-O-Ditrityladenosine

There total 5 articles about N,5'-O-Ditrityladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

trityl chloride (76-83-5) + adenosine (58-61-7) → (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9)

Guidance literature:

With pyridine; at 50 - 60 ℃; for 47h;

DOI:10.1055/s-1985-31332

Reference yield: 51.0%

trityl chloride (76-83-5) + adenosine (58-61-7) → 5'-O-(triphenylmethyl)adenosine (18048-85-6) + (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9)

Guidance literature:

With pyridine; at 50 ℃;

DOI:10.1248/cpb.56.423

Reference yield: 20.5%

trityl chloride (76-83-5) + adenosine (58-61-7) → N6,N7-Ditrityladenine (137964-96-6) + (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol (31085-55-9) + O3',O5',N6-Tritrityladenosine (31085-57-1) + (2R,3R,4R,5R)-5-(6-(tritylamino)-9H-purin-9-yl)-4-(trityloxy)-2-((trityloxy)methyl)tetrahydrofuran-3-ol (31085-56-0)

Guidance literature:

With pyridine; dmap; at 80 ℃;

DOI:10.1021/jo00028a030

upstream raw materials:

pyridine

trityl chloride

adenosine

Downstream raw materials:

2',3'-di-O-trifluoromethylsulfonyl-6-N,5'-O-ditrityladenosine