(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Name:(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
CAS No.:1194688-41-9
Molecular Formula:C₂₅H₃₂N₄O₃
Molecular Weight:436.554
Hs Code.:

Synonyms:(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Property of (3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Technology Process of (3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

There total 3 articles about (3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1194688-40-8
5-bromo-N-(2-methylbenzyl)nicotinamide

: 250275-15-1,1256094-14-0
tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 1194688-41-9
(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; at 95 ℃; for 4h; Inert atmosphere;

Reference yield:

: 89-93-0
ortho-methylbenzylamine

: 1194688-41-9
(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 4 h / 95 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; In dichloromethane; toluene; 2: Buchwald-Hartwig coupling;
DOI:10.1021/jm201045m

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 1194688-41-9
(3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 4 h / 95 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; In dichloromethane; toluene; 2: Buchwald-Hartwig coupling;
DOI:10.1021/jm201045m