(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Base Information

Chemical Name:(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide
CAS No.:203639-74-1
Molecular Formula:C₃₀H₂₇N₃O₄S
Molecular Weight:525.628
Hs Code.:

Synonyms:(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Suppliers and Price of (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Chemical Property:

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Technology Process of (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

There total 3 articles about (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 140645-36-9
(R)-2-(Biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid

: 203639-74-1
(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 6h; Ambient temperature;
DOI:10.1021/jm9707582

Reference yield:

: 1623-93-4
4-diphenylsulfonyl chloride

: 203639-74-1
(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂CO₃ / dioxane / Ambient temperature

2: 80 percent / HOBt*H₂O, N-methylmorpholine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide*HCl / dimethylformamide / 6 h / Ambient temperature

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707582

Reference yield:

: 153-94-6,27732-43-0,80206-30-0,27813-82-7
D-tryptophan

: 203639-74-1
(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂CO₃ / dioxane / Ambient temperature

2: 80 percent / HOBt*H₂O, N-methylmorpholine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide*HCl / dimethylformamide / 6 h / Ambient temperature

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm9707582