N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine

Base Information

• Chemical Name: N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine
• CAS No.: 877128-48-8
• Molecular Formula: C₃₅H₅₀INO₃Si₂
• Molecular Weight: 715.862
• Mol file: 877128-48-8.mol

Synonyms:N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine

Chemical Property of N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine

There total 7 articles about N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

N-benzyl-2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethylamine (877128-46-6) + α-bromoacetophenone (70-11-1) → N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine (877128-48-8)

Guidance literature:

With methyloxirane; In 1,4-dioxane; at 105 ℃;

DOI:10.3987/COM-05-10554

Reference yield:

N-benzoyl-2-[3,4-di(t-butyldimethylsilyloxy)phenyl]ethylamine (877128-42-2) → N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine (877128-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 69.7 percent / iodine; silver trifluoroacetate / CHCl₃ / 20 °C

2: 33.1 percent / BH₃ / tetrahydrofuran / 6 h / Heating

3: 80.8 percent / propylene oxide / dioxane / 105 °C

With borane; iodine; silver trifluoroacetate; methyloxirane; In tetrahydrofuran; 1,4-dioxane; chloroform;

DOI:10.3987/COM-05-10554

Reference yield:

N-benzoyl-2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethylamine (877128-44-4) → N-benzyl-N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}phenacylamine (877128-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 33.1 percent / BH₃ / tetrahydrofuran / 6 h / Heating

2: 80.8 percent / propylene oxide / dioxane / 105 °C

With borane; methyloxirane; In tetrahydrofuran; 1,4-dioxane;

DOI:10.3987/COM-05-10554

upstream raw materials:

N-benzyl-2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethylamine

α-bromoacetophenone

N-benzoyl-2-[3,4-di(t-butyldimethylsilyloxy)phenyl]ethylamine

N-benzoyl-2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethylamine

Downstream raw materials:

3-benzyl-7,8-di(t-butyldimethylsilyloxy)-1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine