[S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide

Base Information

• Chemical Name: [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide
• CAS No.: 124097-84-3
• Molecular Formula: C₁₃H₁₆N₂OS
• Molecular Weight: 248.349
• Mol file: 124097-84-3.mol

Synonyms:[S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide

Chemical Property of [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide

There total 11 articles about [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(S)-2-[(E)-(R)-1-Phenyl-ethylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide (133667-53-5) → (-)-N-methyl-2-oxo-1-(pyridin-3-yl)cyclohexanecarbothioamide (124034-07-7) + [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide (124097-84-3)

Guidance literature:

With oxonium;

DOI:10.1016/S0040-4039(00)60875-4

Reference yield:

→ [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide (124097-84-3) + rac-methylbenzylamine (618-36-0)

Guidance literature:

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide (124097-84-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) Et₂O, -78 deg C

2: conc. H₂SO₄

3: H₂O

4: PTSA / toluene / Heating

5: 1) n-BuLi / 1) THF, -78 deg C

6: 44 percent / H₃O⁺

With n-butyllithium; sulfuric acid; oxonium; water; toluene-4-sulfonic acid; In toluene;

DOI:10.1016/S0040-4039(00)60875-4

upstream raw materials:

(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide

(S)-2-[(E)-(R)-1-Phenyl-ethylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide

3-Bromopyridine

2-methoxycyclohexanone

Downstream raw materials:

[1S,2R]-trans-2-hydroxy-N-methyl-1-(pyridin-3-yl)cyclohexanecarbothioamide

[1S,2R]-trans-2-Benzoyloxy-N-methyl-1-(pyrid-3-yl)cyclohexanecarbothioamide

C₂₇H₂₆N₂O₃S