124034-07-7

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 626-55-1 3-Bromopyridine 
• 7429-44-9 2-methoxycyclohexanone 
• 124034-66-8 2-(pyridin-3-yl)-cyclohexanone 
• 124034-67-9 trans-1-[(pyridin-3-yl)bromomethyl] cyclopentanol 
• 124034-68-0 3-cyclopentylidenemethylpyridine 
• 556-61-6 methyl thioisocyanate 
• 133667-53-5 (S)-2-[(E)-(R)-1-Phenyl-ethylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 145931-38-0 ((R)-1-Phenyl-ethyl)-[2-pyridin-3-yl-cyclohex-(E)-ylidene]-amine 
• 148322-26-3 (+)-2-methoxy-1-(pyrid-3-yl)cyclohexanol 

Downstream Products

• 131332-01-9 (+/-)-2-Cyanomethylene-N-methyl-1-(pyrid-3-yl)-cyclohexane carbothioamide 
• 146035-38-3 2-Benzyl-7-pyridin-3-yl-4,5,6,7-tetrahydro-2H-indazole-7-carbothioic acid methylamide; hydrochloride 
• 146035-33-8 3-[1-Dimethylamino-meth-(E)-ylidene]-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 133219-30-4 Benzoic acid (1S,2R)-2-methylthiocarbamoyl-2-pyridin-3-yl-cyclohexyl ester 
• 134121-97-4 (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester 
• 134121-96-3 (1S,2R)-2-Methoxy-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 

Relevant academic research and scientific papers

Thioformamide derivatives

Thioformamide compounds of formula (I) are disclosed in which R is alkyl, Y is methylene, ethylene or a direct bond, A is optionally substituted phenyl or pyridyl, R1 is hydrogen and R2 is N-alkylsulphonyl-, N-phenylsulphonyl-N'-alky

Syntheses and Biological Activities of Potent Potassium Channel Openers Derived from (+/-)-2-Oxo-1-pyridin-3-yl-cyclohexanecarbothioic Acid Methylamide: New Potassium Channel Openers

The syntheses and biological activities of (+/-)-2-(cyanomethylene)-1-pyridin-3-ylcyclohexanecarbothioic acid methylamide (6) and trans-(+/-)-2-(cyanomethyl)-1-pyridin-3-ylcyclohexanecarbothioic acid methylamide (14) derived from (+/-)-2-oxo-1-pyridin-3-y

Thioformamide derivatives

Thioformamide derivatives of the formula (I) STR1 wherein R represents an alkyl group; A represents either: (1) a phenyl group which is optionally substituted; or (2) heteroaromatic group (e.g. pyrid-3-yl, quinolin-3-yl); Y represents: an ethylene or methylene group or a direct bond; and B represents either: a) a phenyl, pyridyl, furyl or thienyl group, each of which may be optionally substituted, or b) a straight- or branched-chain alkyl, alkenyl, or cycloalkyl group, each of which may be optionally substituted. These compounds may be formulated into pharmaceutical preparations and have utility in the treatment of disorders associated with smooth muscle contraction.

The synthesis of RP 66471. A potent potassium channel opener

The potent, homochiral, potassium channel opener, RP 66471, has been synthesised and shown to possess the (1R,2S) configuration.

The Synthesis of RP 65479. A Novel, Potent Potassium Channel Opener.

The potent potassium channel opener, 4, RP 65479, has been synthesized from the key intermediate, 2-(3-pyridyl)cyclohexanone, 8.

Derivatives of thioformamide

Therapeutically useful thioformamide derivatives of the formula: STR1 wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C=NOR1, >C=NN(R1)2 or >C=NN(R1)CON(R1)2 in which R1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.

Thioformamide derivatives

Thioformamide derivatives of the formula: STR1 wherein: R represents alkyl; A represents an optionally substituted phenyl or heteroaromatic group; R1 represents hydrogen, alkyl, cyano, carboxyl, formyl, carbamoyl, alkoxycarbonyl or a group --(C

Pyrid-3-yl thioformamide compounds which have useful pharmaceutical utilities

This invention relates to a thioformamide derivative of the formula I STR1 wherein: R and R1 each independently represent an alkyl group; A represents either: (1) a phenyl group which is optionally substituted; or (2) a heteroaromatic group (e.

Thioformamide derivatives

Thioformamide derivatives of the formula: wherein R represents alkyl of 1 to 4 carbon atoms;, Het represents optionally substituted pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3--b]pyridin-5-yl, pyrazin-2-yl, indol-3-yl or thieno-[3,2--b]pyridin-6-yl;, and R1 represents a benzyl radical substituted on the ring by two to five fluorine atoms, and salts thereof are therapeutically useful.