(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

Base Information

Chemical Name:(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide
CAS No.:831235-50-8
Molecular Formula:C₄₅H₅₉BrN₂O₂SSi
Molecular Weight:800.031
Hs Code.:

(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

Synonyms:(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

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Chemical Property of (S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

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Technology Process of (S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

There total 9 articles about (S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 831235-47-3
Methanesulfonic acid (R)-2-[(1R,4aS,5R,7S,8aR)-7-(tert-butyl-diphenyl-silanyloxy)-5-((S)-1-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-ethyl)-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-3-methyl-butyl ester

: 831235-50-8
(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

Guidance literature:: With lithium bromide; In acetone; for 48h; Heating;
DOI:10.1021/jo048456c

Reference yield:

: 37845-64-0
2-Cyanoethyl 2-(Methylamino)phenyl Sulfide

: 831235-50-8
(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 11 mg / K₂CO₃ / tetrahydrofuran / 20 °C

2: 88 percent / LiBr / acetone / 48 h / Heating

With potassium carbonate; lithium bromide; In tetrahydrofuran; acetone;
DOI:10.1021/jo048456c

Reference yield:

: 831235-45-1
Methanesulfonic acid (R)-2-[(1R,4aS,5R,7S,8aR)-7-(tert-butyl-diphenyl-silanyloxy)-3-methyl-5-((S)-1-methyl-2-oxo-ethyl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-3-methyl-butyl ester

: 831235-50-8
(S)-2-[(1R,3S,4aR,5R,8aS)-5-((R)-1-Bromomethyl-2-methyl-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-N-[2-(2-cyano-ethylsulfanyl)-phenyl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄*H₂O / 2-methyl-propan-2-ol; acetonitrile / 2 h / 20 °C

2: (COCl)2 / benzene / 3 h / 20 - 50 °C

3: 11 mg / K₂CO₃ / tetrahydrofuran / 20 °C

4: 88 percent / LiBr / acetone / 48 h / Heating

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; potassium carbonate; lithium bromide; In tetrahydrofuran; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jo048456c