tert-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucine benzyl ester

Base Information

• Chemical Name: tert-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucine benzyl ester
• CAS No.: 100642-98-6
• Molecular Formula: C64H111 N9 O12
• Molecular Weight: 1198.6192
• Mol file: 100642-98-6.mol

Synonyms:L-Leucine,N-[N-[N-[N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leucyl]-L-leucyl]-2-methylalanyl]-L-leucyl]-L-leucyl]-L-leucyl]-,phenylmethyl ester

Chemical Property of tert-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucine benzyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1249.5°Cat760mmHg
• Flash Point: 709.5°C
• PSA: 297.43000
• Density: 1.074g/cm³
• LogP: 10.79840

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucine benzyl ester

There total 2 articles about tert-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Boc-Leu-Leu-Leu-Leu-Aib-OH (99593-08-5) + H-Leu4-OBzl (773809-29-3) → Boc-L-Leu4-Aib-L-Leu4-OBzl (100642-98-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.58.1731

Reference yield: 50.0%

Boc-L-Leu4-OH (18868-24-1) + TFA*H-Aib-L-Leu4-OBzl → Boc-L-Leu4-Aib-L-Leu4-OBzl (100642-98-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1246/cl.2000.366

Reference yield: 61.0%

Boc-L-Leu4-Aib-L-Leu4-OBzl (100642-98-6) + trifluoroacetic acid (76-05-1) → TFA*H-L-Leu4-Aib-L-Leu4-OBzl

Guidance literature:

DOI:10.1246/cl.2000.366

upstream raw materials:

Boc-Leu-Leu-Leu-Leu-Aib-OH

H-Leu₄-OBzl

Boc-L-Leu₄-OH

Refernces

• 1、 Narita, Mitsuaki,Ishikawa, Kazunori,Sugasawa, Hiroki,Doi, Masamitsu. "The Ability of an α-Aminoisobutyric Acid Residue to Promote Helical Folding in Oligopeptides". . p. 1731 - 1737. Retrieved 2007/10/02.