3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Base Information Edit

Chemical Name:3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
CAS No.:1257628-83-3
Molecular Formula:C₂₁H₁₆F₃N₃O
Molecular Weight:383.373
Hs Code.:
Mol file:1257628-83-3.mol

Synonyms:3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Suppliers and Price of 3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

There total 7 articles about 3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 926922-18-1
3-iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide

: 1066-54-2
trimethylsilylacetylene

: 1257628-83-3
3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: 3-iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide; trimethylsilylacetylene; With copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine; In acetonitrile; at 80 ℃; for 2h; Sealed tube; Inert atmosphere;

With potassium carbonate; In methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2015.07.006

Reference yield:

: C₂₄H₂₄F₃N₃OSi

: 1257628-83-3
3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 3h;

Reference yield:

: 82998-57-0
3-iodo-4-toluic acid

: 1257628-83-3
3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; thionyl chloride / 2 h / Reflux

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

4: potassium carbonate; methanol / 3 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; acetonitrile;