3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Base Information

• Chemical Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
• CAS No.: 641571-11-1
• Molecular Formula: C11H10F3N3
• Molecular Weight: 241.216
• Hs Code.: 2933290090
• Mol file: 641571-11-1.mol

Synonyms:1-(3-Amino-5-trifluoromethylphenyl)-4-methyl-1H-imidazole;

Chemical Property of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 124-126°C
• Refractive Index: 1.553
• Boiling Point: 379.805 °C at 760 mmHg
• Flash Point: 183.5 °C
• PSA: 43.84000
• Density: 1.35 g/cm³
• LogP: 3.36290
• Storage Temp.: Refrigerator
• Water Solubility.: 228.6mg/L at 25℃

Purity/Quality:

98%min. ^*data from raw suppliers

3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

There total 28 articles about 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.18%

4-methyl-1H-imidazole (822-36-6) + [3-bromo-5-(trifluoromethyl)phenyl]amine (54962-75-3) → 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1)

Guidance literature:

With copper(l) iodide; (+)-D-glucosamine hydrochloride; caesium carbonate; In water; dimethyl sulfoxide; at 90 ℃; for 12h; Temperature; Concentration;

Reference yield: 92.8%

C23H18F6N6O → 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1)

Guidance literature:

With sodium hydroxide; In m-xylene; isopropyl alcohol; for 25h; Reflux;

Reference yield: 90.0%

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzohydrazide → 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1)

Guidance literature:

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzohydrazide; With sulfuric acid; sodium nitrite; In methanol; at 15 - 25 ℃; for 0.416667h;

In methanol; at 55 - 75 ℃; for 0.416667h; Concentration; Reagent/catalyst; Temperature;

upstream raw materials:

4-methyl-1H-imidazole

[3-bromo-5-(trifluoromethyl)phenyl]amine

4-methyl-1-(3-nitro-5-(trifluoromethyl)-phenyl)-1H-imidazole

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline hydrochloride

Downstream raw materials:

6-methyl-N-{3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl}-5-[4-(pyrid-3-yl)pyrimid-2-yl-amino]nicotinamide

3-iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide

nilotinib

[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-[4-(4-methyl-thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine

Refernces

• 1、 -. "SUBSTITUTED ARYLUREA COMPOUNDS FOR INDUCING APOPTOSIS AND COMPOSITION FOR ANTICANCER COMPRISING THE SAME". Paragraph 0141-0145. . Retrieved 2021/08/17.
• 2、 Bonnar, James,Dixon, Ian,Evison, Benny J.,Kelly, Graham E.,Kumar, Sanjay,Lambert, Gilles,Nativel, Brice,Palmer, James T.,Parmar, Jasneet,Rathi, Anuj Kumar,Suchowerska, Alexandra K.,Tang, Wei,Teng, Yanfen,Treutlein, Herbert,Wang, Jie,Xu, Yanfeng,Zeng, Jun,Zhu, Qing,Chemello, Kévin. "A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove". supporting information. . Retrieved 2020/02/13.