(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

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Chemical Name:(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester
CAS No.:828921-14-8
Molecular Formula:C₄₀H₄₈N₂O₁₃S₂
Molecular Weight:828.959
Hs Code.:

(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

Synonyms:(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

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Chemical Property of (2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

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Technology Process of (2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

There total 11 articles about (2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 828921-13-7
(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2,2-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

: 828921-14-8
(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

Guidance literature:: With trifluoroacetic acid; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1021/ja044702q

Reference yield:

: 57009-70-8
2-(3,4,5-trimethoxyphenyl)-1,3-dithiane

: 828921-14-8
(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tBuLi / tetrahydrofuran; pentane / -40 - -10 °C

1.2: 58 percent / tetrahydrofuran; pentane / -20 - 20 °C

2.1: 510 mg / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C

3.1: 1,4-cyclohexadiene / acetonitrile / 1 h / UV-irradiation

3.2: 94 percent / Me₂S / acetonitrile / 4 h / 20 °C

4.1: 99 percent / (1-azabenzotriazole-1-yloxy)tripyrrolidinophosphonium*BF₆; TEA / CH₂Cl₂ / 4 h / 20 °C

5.1: 97 percent / aq. TFA / acetonitrile / 0.5 h / 20 °C

With pyridine; dmap; cyclohexa-1,4-diene; (1-azabenzotriazole-1-yloxy)tripyrrolidinophosphonium*BF₆; TEA; tert.-butyl lithium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; pentane;
DOI:10.1021/ja044702q

Reference yield:

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 828921-14-8
(2S,4R)-2-Phenethylcarbamoyl-4-[2-(3,4,5-trimethoxy-phenyl)-[1,3]dithian-2-ylmethoxycarbonyloxy]-pyrrolidine-1-carboxylic acid 2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 96 percent / KOH; iodobenzene diacetate / 18 h / 20 °C

2.1: TEA / tetrahydrofuran; toluene / 1.33 h / 0 - 20 °C

3.1: aq. Na₂CO₃ / tetrahydrofuran / 0 - 20 °C

4.1: 1.90 g / Cs₂CO₃ / dimethylformamide / 0.42 h / 0 - 20 °C

5.1: TEA / tetrahydrofuran; toluene / 1.08 h / 0 - 20 °C

6.1: 510 mg / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C

7.1: 1,4-cyclohexadiene / acetonitrile / 1 h / UV-irradiation

7.2: 94 percent / Me₂S / acetonitrile / 4 h / 20 °C

8.1: 99 percent / (1-azabenzotriazole-1-yloxy)tripyrrolidinophosphonium*BF₆; TEA / CH₂Cl₂ / 4 h / 20 °C

9.1: 97 percent / aq. TFA / acetonitrile / 0.5 h / 20 °C

With pyridine; dmap; potassium hydroxide; [bis(acetoxy)iodo]benzene; cyclohexa-1,4-diene; (1-azabenzotriazole-1-yloxy)tripyrrolidinophosphonium*BF₆; TEA; sodium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja044702q