1136-86-3

Basic information

• Product Name: 3',4',5'-TRIMETHOXYACETOPHENONE
• Synonyms: 3',4',5'-TRIMETHOXYACETOPHENONE;3,4,5-TRIMETHOXYACETOPHENONE;AKOS 217-16;LABOTEST-BB LT00233192;1-(3,4,5-Trimethoxyphenyl)ethanone;Acetophenone, 3',4',5'-trimethoxy;3,4,5-'Trimethoxyacetophenone98%;Ethanone, 1-(3,4,5-trimethoxyphenyl)-
• CAS NO: 1136-86-3
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• EINECS: 214-501-9
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 1136-86-3.mol
• Article Data: 32

Chemical Properties

• Melting Point: 78-80 °C(lit.)
• Boiling Point: 173-174 °C10 mm Hg(lit.)
• Flash Point: 173-174°C/10mm
• Appearance: white to yellow crystalline powder
• Density: 1.1922 (rough estimate)
• Refractive Index: 1.5075 (estimate)
• Storage Temp.: Store below +30°C.
• Water Solubility: Slightly soluble in water.
• BRN: 1463133
• CAS DataBase Reference: 3',4',5'-TRIMETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4',5'-TRIMETHOXYACETOPHENONE(1136-86-3)
• EPA Substance Registry System: 3',4',5'-TRIMETHOXYACETOPHENONE(1136-86-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 22-24/25-45-36/37/39-27-26
• WGK Germany: 3
• Hazardous Substances Data: 1136-86-3(Hazardous Substances Data)

Usage

Chemical Properties

white to yellow crystalline powder

Uses

3',4',5'-Trimethoxyacetophenone is used in agrochemical, pharmaceutical and dyestuff field .

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by methoxy groups at positions 3, 4 and 5 respectively.

Preparation

Obtained by treatment of a mixture of methyl 3,4,5-trimethoxybenzoate (m.p. 82°) and ethyl acetate with sodium on a water boiler for 8 h, then with 25% sulfuric acid.

Upstream product

• 3044-56-2 ethyl trimethoxybenzoyl acetate 
• 506-82-1 dimethylcadmium 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 917-54-4 methyllithium 
• 118-41-2 Eudesmic acid 
• 917-64-6 methyl magnesium iodide 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 3086-62-2 3,4,5-trimethoxybenzamide 
• 266329-23-1 (dimethylphenylsilyl)(3,4,5-trimethoxyphenyl)methanone 
• 227624-38-6 (dimethylphenylsilyl)(3,4,5-trimethoxyphenyl)methanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 266329-28-6 1-(dimethylphenylsilyl)-1-(3,4,5-trimethoxyphenyl)ethanol 

Downstream Products

• 1041-10-7 3-(piperidin-1-yl)-1-(3,4,5-trimethoxyphenyl)propan-1-one hydrochloride 
• 6307-90-0 3,4,5-trimethoxy-1-nitrobenzene 
• 33709-29-4 1-(3,4,5-trihydroxyphenyl)-ethan-1-one 
• 130768-87-5 (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 127033-98-1 (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 110048-17-4 3',4,4',5'-tetramethoxychalcone 
• 70909-47-6 ethyl 2,4-dioxo-4-(3,4,5-trimethoxyphenyl)butanoate 
• 3044-56-2 ethyl trimethoxybenzoyl acetate 
• 101256-79-5 3-morpholin-4-yl-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 61196-72-3 3-(pyridin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 127034-42-8 3',4',5'-trimethoxy-3-(4-pyridyl)-acrylophenone 
• 127034-43-9 (E)-3-(2-thienyl)-1-(3,4,5-trimethoxyphenyl)-3-phenylprop-2-en-1-one 
• 127034-11-1 (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(4-nitrophenyl)-2-propen-1-one 
• 127034-19-9 1-(3,4,5-trimethoxyphenyl)-3-[4-(diethylamino)phenyl]prop-2-en-1-one 

Relevant articles and documents

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Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation

A practical and general iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.

Sequential Cleavage of Lignin Systems by Nitrogen Monoxide and Hydrazine

The cleavage of representative lignin systems has been achieved in a metal-free two-step sequence first employing nitrogen monoxide for oxidation followed by hydrazine for reductive C?O bond scission. In combining nitrogen monoxide and lignin, the newly developed valorization strategy shows the particular feature of starting from two waste materials, and it further exploits the attractive conditions of a Wolff-Kishner reduction for C?O bond cleavage for the first time. (Figure presented.).

Aerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese

The oxidation of alcohols to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alcohol is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcohols, secondary alcohols, 1,2-diols, 1,2-amino alcohols, and other α-functionalized alcohols using a commercially available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the experimental results and literature was proposed.