5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

Base Information

Chemical Name:5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide
CAS No.:1396243-13-2
Molecular Formula:C₂₀H₁₈FNO₃S
Molecular Weight:371.432
Hs Code.:

Synonyms:5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

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Chemical Property of 5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

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Technology Process of 5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

There total 3 articles about 5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1396244-24-8
5-bromo-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 1396243-13-2
5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jm3014053

Reference yield: 72.0%

: 1396243-13-2
5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:

Reference yield:

: 31555-60-9
5-bromothiophene-2-carbonyl chloride

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

: 1396243-13-2
5-(2-fluoro-3-methoxyphenyl)-N-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 3 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 14 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; water;
DOI:10.1021/jm3014053