(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

Base Information

Chemical Name:(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene
CAS No.:930767-53-6
Molecular Formula:C₂₅H₄₂O₃SSi
Molecular Weight:450.758
Hs Code.:

Synonyms:(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

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Chemical Property of (1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

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Technology Process of (1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

There total 3 articles about (1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 994-30-9
triethylsilyl chloride

: 239100-21-1
(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]octahydro-1H-inden-4-ol

: 930767-53-6
(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.steroids.2005.11.001

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 930767-53-6
(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaI / acetone / 2.5 h / Heating

1.2: 78 percent / dimethylformamide / 18 h / 20 °C

2.1: 100 percent / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; sodium iodide; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.steroids.2005.11.001

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 930767-53-6
(1R,3aR,4S,7aR)-7a-methyl-1-[(1S)-1-methyl-1-(phenylsulfonyl)ethyl]-4-(triethylsilyloxy)octahydro-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / DMAP / pyridine

2.1: NaI / acetone / 2.5 h / Heating

2.2: 78 percent / dimethylformamide / 18 h / 20 °C

3.1: 100 percent / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; dmap; sodium iodide; In pyridine; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.steroids.2005.11.001