6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

Base Information

Chemical Name:6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate
CAS No.:112089-52-8
Molecular Formula:C₁₉H₂₀N₂O₇S
Molecular Weight:420.443
Hs Code.:

Synonyms:6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

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Chemical Property of 6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

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Technology Process of 6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

There total 10 articles about 6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 112089-54-0
6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-1H-indole-3-methanol acetate

: 112089-52-8
6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

Guidance literature:: With nitric acid; In nitromethane; at 0 ℃; for 0.666667h;
DOI:10.1021/jm00398a017

Reference yield:

: 106014-83-9
2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol

: 112089-52-8
6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

2: 111 g / pyridine / 1.42 h / 5 °C

3: 1.) sodium acetate, 2.) triethylamine / 1.) ethanol, reflux, 20 h, 2.) methylene chloride

4: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

With pyridine; hydrogen; nitric acid; sodium acetate; triethylamine; platinum(IV) oxide; In nitromethane; ethanol;
DOI:10.1021/jm00398a017

Reference yield:

: 610-78-6
3-nitro-4-chlorophenol

: 112089-52-8
6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-5-nitro-1H-indole-3-methanol acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / K₂CO₃ / acetone; dimethylformamide / 64 h / Ambient temperature

2: 77 percent / NaH / dimethylsulfoxide / 24 h / 105 - 115 °C

3: 40 percent / diisobutylaluminum hydride / tetrahydrofuran / 2.3 h / Ambient temperature

4: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

5: 111 g / pyridine / 1.42 h / 5 °C

6: 1.) sodium acetate, 2.) triethylamine / 1.) ethanol, reflux, 20 h, 2.) methylene chloride

7: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

With pyridine; hydrogen; nitric acid; sodium acetate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; nitromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00398a017