112089-54-0Relevant articles and documents
Tumorselektiv aktivierbare Prodrugs des Cytostaticums CC-1065
Tietze, Lutz F.,Hannemann, Robert,Buhr, Wilm,Loegers, Michael,Menningen, Pia,et al.
, p. 2840 - 2842 (2007/10/03)
Keywords: Cytostatica; Enzyme; β-Galactosidase; β-Glucosidase; Heck-Reaktionen
Total Synthesis of U-71,184, A Potent New Antitumor Agent Modeled on CC-1065
Warpehoski, M.A.
, p. 4103 - 4106 (2007/10/02)
The synthesis of U-71,184 (2), a highly potent analog of the novel antitumor antibiotic CC-1065, is described, the penultimate step of which involves the unmasking of a p-hydroxy phenethyl mesylate, which undergoes facile intramolecular elimination to aff