N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine

Base Information

• Chemical Name: N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine
• CAS No.: 1380429-40-2
• Molecular Formula: C₁₇H₁₇ClF₃N₃O
• Molecular Weight: 371.79

Synonyms:N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine

Chemical Property of N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine

Chemical Property:

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Technology Process of N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine

There total 1 articles about N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

{2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-ethyl}-methyl-amine (1380430-82-9) + 1H-Pyrazole-1-carboxamidine (4023-00-1) → N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine (1380429-40-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 22.4%

methyl 2-formyl-3-(5-pyrimidinyl)propanoate (1380429-19-5) + N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine (1380429-40-2) → 2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone (1380426-91-4)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 3h; Microwave irradiation;

Reference yield: 20.5%

methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate (1380429-22-0) + N-[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]-N-methylguanidine (1380429-40-2) → 2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone (1380426-89-0)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 2h; Microwave irradiation;

upstream raw materials:

{2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-ethyl}-methyl-amine

1H-Pyrazole-1-carboxamidine

Downstream raw materials:

2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

2-[[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl](methyl)amino]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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